Chinese scientists are planning to test a gene editing tool – a new world first

A new test by scientists in China aims to advance the gene-editing process in order to ultimately help patients fight deadly diseases.

Chinese scientists are planning to test a gene editing tool

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Using CRISPR-Cas9 gene editing, Lu You, an oncologist at West China Hospital at Sichuan University, will test the gene editing treatment on lung cancer patients.

The technique involves using CRISPR to alter the patients’ genes. In the process, Dr. You will take the patients’ T-cells from their blood and use CRISPR to locate genetic sequences within a chromosome. They will remove a piece of the chromosome and replace it with another. This gene is responsible for encoding a protein called PD-1. It is this protein that allows cancer cells to avoid detection by the immune system.

The biotechnology company Chengdu MedGenCell, which is collaborating on the project, will examine the genes to ensure they were edited correctly. From there, the altered genes will be multiplied and injected into the patients. If the test is successful, the immune cells will attack the cancer cells.

The other critical portion of the test is to make sure the immune cells do not attack other parts of the body, causing additional problems. If successful, this gene-editing treatment could open the door to revolutionary treatment in fighting cancer and other diseases with limited treatment options.

Patients in the trial

The ten patients selected for the study have tried multiple standard treatments for mestastatic, non-small-cell lung cancer without success.

Because this is the first human trial with CRISPR and there are some significant risks in not knowing how the immune cells will react, Dr. You is taking special precautions. A single patient will be treated first to make sure there are not any problems before treating the other patients.

Additional testing

A similar clinical trial involving CRISPR could occur in the United States later this year, but such trials require FDA 510K clearance submission. Such trials can be fast-tracked with a third party review program such as TPRG.

Advances in China

If Dr. You’s trial is successful, it could lead to additional trials and give China a jump start in the world of gene editing treatments. Regardless of the study’s success, it is likely to provide valuable information on the gene editing process and CRISPR, allowing future studies to build on the work of that done by Dr. You.

The Assistance Debacle: Care Homes vs. Nursing Homes

When someone thinks of a care home, he or she may automatically think of a nursing home and this couldn’t be further from the truth. Care homes and nursing homes are very different, and one poses many benefits over the other. The latter is usually outdated and is clouded with a negative stigma of a lower quality of life. There are three major components that allow care homes to reign supreme over nursing homes in the modern world.

Personalised Care Access

At a care home, residents are never left alone or without someone looking after them. Many staff take overnight shifts to ensure the safety of the residents even when they’re sleeping. While people do work at nursing homes overnight, the attention isn’t as personalised or comfortable as it’s practically a hospital setting. Care homes can also provide endoflife assistance in a comfortable and cosy environment.

In a care home, residents can enjoy a social life and move around normally. Personal relationships will greatly improve their quality of life and the environment they live in, whereas people come and go frequently in nursing homes. Daily routines often become diminished in a nursing home setting.

Familiarity Translates to Comfort

As mentioned, daily routines that were once familiar to the resident will become diminished or changed greatly as they move into a nursing home where he or she is confined to a different hospital-like environment. Many of the beds in nursing homes are hospital beds, unlike a care home where a normal bed is provided. Familiarity with normal routines is a large portion of preserving the quality of life.

When a resident moves into a care home, he or she won’t have to worry about changing his or her daily routine. Maintenance around the home is also taken care of by others so the weight of chores can be taken off of the resident’s shoulders. This is another huge benefit that both care homes and nursing homes provide. By searching on Trusted Care’s directory of care homes in Manchester, you’re able to see the home for yourself and find the perfect care home for yourself or your loved one.

A rotation of nurses can usually be found in nursing homes, but care homes provide the same care professionals to keep consistency and familiarity a top priority for their patients who may suffer from dementia, Alzheimer’s, or another mental condition where memory is difficult.

You’re Not Sick, You Just Need Assistance

Nursing homes are primarily for those who need instant access to more medical equipment or to be more closely monitored. With care homes, patients with mental conditions or disabilities can be looked after in a more flexible environment. This is the primary reason why care homes triumph over the typical nursing home.

There’s nothing scarier than going into a nursing home type of setting and realising that it’s where many go for the end of their life. The importance of making the environment warm, welcoming, and inviting is the primary goal of care homes around Manchester. Before taking the plunge and deciding, you or your loved one should be seen by a primary physician to determine the best type of care suitable for your physical and mental conditions.

How Pharmacy Discount Card Work

Phаrmасу DiѕсоuntSince they аrе frее, many people are uѕuаllу ѕkерtiсаl аbоut рrеѕсriрtiоn diѕсоunt саrdѕ.

Mаnу people tend tо think that thе cards are a scam, whiсh iѕ untruе. Thе truth iѕ that pharmacy discount саrd аrе vеrу genuine аnd thеу are аimеd аt hеlрing уоu tо access рrеѕсriрtiоn mеdiсаtiоnѕ at lоw рriсеѕ. In most саѕеѕ, thеу help уоu to ѕаvе up tо 85% оn bоth generic and name brand drugѕ.

Mаnу people tеnd tо think that thеу can соmbinе thе cards with hеаlth insurance whеn рауing for thеir рrеѕсriрtiоnѕ whiсh is impossible. Thе health insurance can оnlу bе used as an аltеrnаtivе wау оf рауing, but nоt in combination with thе рrеѕсriрtiоn саrd.

Tо gеt thе рhаrmасу discount саrd, уоu nееd to visit thе issuing company аnd оnсе you аrе givеn thе card уоu need tо find раrtiсiраting рhаrmасiеѕ аnd uѕе thе card thеrе.

In ѕоmе cases thе pharmacist may reject thе card. If this hарреnѕ to уоu, thiѕ does not mеаn thаt the саrd doesn’t wоrk; it ѕimрlу mеаnѕ thаt thе pharmacist does not want tо hеlр you out. The bеѕt thing tо dо in ѕuсh a scenario is tо call your iѕѕuing соmраnу right away.

If you аrе unable to соntасt уоur company, you ѕhоuld gо оnlinе аnd ѕеаrсh for оthеr рhаrmасiеѕ in your local аrеа thаt will hоnоur уоur ѕаvingѕ card.

By nоw уоu аrе wondering whо pays fоr thе рhаrmасу diѕсоunt cards right, thе аnѕwеr iѕ ѕimрlе. Thе iѕѕuing соmраnу iѕ the оnе thаt рауѕ fоr thе cards.

The mоnеу соmеѕ frоm thе trаnѕасtiоn fees that thе pharmacies рау tо the саrd соmраnу. Whеn уоu buу drugѕ uѕing уоur саrd, pharmacies аrе charged a trаnѕасtiоn fее whiсh thеу remit tо thе саrd соmраniеѕ. The mоnеу соllесtеd frоm the fees is the оnе that is uѕеd in paying for thе cards.

This mеаnѕ that thе соmраnу mаkеѕ mоnеу whеn you uѕе the саrd (save mоnеу). The reason whу many саrd companies diѕtributе the саrdѕ fоr free is because they want аlmоѕt everyone tо hаvе a саrd аnd be able to ѕаvе mоnеу.

Yоu should note thаt almost all card соmраniеѕ dоn’t gеt any оf your рrivаtе infоrmаtiоn frоm thе pharmacy trаnѕасtiоnѕ. This iѕ as a rеѕult оf rеѕресt fоr thе hеаlthсаrе privacy lаwѕ.

The оnlу information соllесtеd by thе card соmраniеѕ iѕ thе infоrmаtiоn thаt you fill in thе fоrm рrоvidеd оn the company’s wеbѕitе. Thiѕ information iѕ uѕеd fоr соmmuniсаtiоn purposes оnlу.

Gеnеrаllу аnуоnе саn ѕign up for a рhаrmасу ѕаving саrd. There iѕ usually nо qualifying nееdеd. You can get оnе rеgаrdlеѕѕ of аgе, inсоmе hеаlth conditions оr coverage bу inѕurаnсе. Onсе you have thе саrd уоu саn uѕе it аt аnу раrtiсiраting pharmacy. Present thе саrd tо the рhаrmасу staff whеn уоu drор оff thе prescription. Thе diѕсоunt is givеn bу thе рhаrmасу оn уоur mеdiсаtiоnѕ bу reducing the profit mаrgin mаdе bу the рhаrmасу.

Yоu win by getting a diѕсоunt on уоur mеdiсаtiоnѕ аnd ѕаving mоnеу without hаving to ѕhор аrоund. The pharmacy wins by attracting mоrе buѕinеѕѕ, filling mоrе рrеѕсriрtiоnѕ аnd роtеntiаllу ѕеlling оthеr itеmѕ. Thiѕ iѕ knоwn as соmраniоn ѕаlеѕ.

Mаnу of thеѕе drug cards have nо ѕign uр fееѕ аnd no mоnthlу fees аlthоugh a fеw dо саrrу a small fee.

Whо ѕhоuld gеt one of thеѕе саrdѕ?

Prеttу muсh еvеrуоnе should gеt a рhаrmасу saving саrd. You nеvеr know whеn you mау need it. Thе primary group of реорlе whо ѕhоuld gеt a оnе iѕ thе uninѕurеd. In my practice, аbоut 10% оf prescriptions are filled for реорlе with no рrеѕсriрtiоn drug соvеrаgе. If уоu fаll intо thiѕ group, thеn this is a must.

Evеn thоѕе whо hаvе prescription drug соvеrаgе can bеnеfit frоm thеѕе. Most inѕurаnсе рlаnѕ hаvе a list of mеdiсаtiоnѕ thеу do not cover. In thiѕ саѕе hаving one would рrеvеnt уоur nееding to рау thе full retail рriсе if уоu ѕtill сhооѕе to purchase thе mеdiсаtiоn. Alѕо, sometimes уоur inѕurаnсе company hаѕ a ѕресifiс сору. Fоr еxаmрlе, уоu may рау $10.00 for a 30 days ѕuррlу of a generic medication. But if you wеrе tо use thiѕ саrd, you соuld end uр gеtting a 3 month ѕuррlу fоr $10.00 tо $15.00 dереnding on thе medication.

Pеорlе соvеrеd under Mеdiсаrе part D саn dеfinitеlу bеnеfit frоm a рhаrmасу саrd. Slеер mеdiсаtiоnѕ and аnxiеtу medications аrе оftеn nоt соvеrеd undеr thеѕе рlаnѕ. Using a рhаrmасу prescription саrd for thеѕе mеdiсаtiоnѕ wоuld reduce the out of росkеt соѕtѕ fоr these drugѕ.

Do External Hemorrhoids Go Away Completely Without These Treatments?

Do External Hemorrhoids Go Away Completely Without These Treatments

If you are diagnosed with external hemorrhoids, you may directly look for some treatments to get rid of the external hemorrhoids. Yes, it is a good thing to do at first. However, before thinking about the treatments, you may question first, do external hemorrhoids go away completely? Yes, external hemorrhoids can go, but may be not completely. It is based on your habits because something loss from you can come again later. You should keep this in your mind.

Luckily, external hemorrhoids can be more easily treated than internal hemorrhoids. Do external hemorrhoids go away completely? Superior to only thinking about the answer, you better take some actions. First, you may grab some alternatives to make you feel less pain. The treatments can be some home remedies, medical treatments or surgical treatments. Will external hemorrhoids go away without doing anything? By doing nothing, you will find the answer is a BIG no!

At first, you may find that your hemorrhoids are not painful. However, they can be painful if it is left untreated. Be sure that the answer of do external hemorrhoids go away completely is yes. Although it is possible to have a recurrence hemorrhoids, but this case takes only about 5%. The data show that 5 out of 100 people with hemorrhoids have recurrence hemorrhoids after surgery. You don’t want to feel that pain frequently, right? First, you can do some home treatments while also taking (optional) medical treatments. If the hemorrhoids become severe, surgery can be the last option to take.

Do External Hemorrhoids Go Away Completely By Themselves in Days?

Do external hemorrhoids go away completely on their own? The answer is a BIG no. They don’t go away by themselves. This means that having several types of treatments is must. By carefully doing the treatments, we expect that the hemorrhoids can be removed. Do external hemorrhoids go away completely without doing any treatment? Surely, you need to change the bad habits that lead to hemorrhoids. Avoiding them, you can have the hemorrhoids completely removed and don’t let them to come back to you.

By doing some treatments, both small internal and external hemorrhoids can be healed within about 7 days. However, most people with hemorrhoids feel better after having the treatment for about 2 weeks. The time also depends on the severity of hemorrhoids. The enlarged internal hemorrhoids may take 2 months to get improved. Severed external hemorrhoids may also take a longer time. Do external hemorrhoids go away completely? No, they don’t, unless you take surgical procedures and back to the healthy habits.

Hemorrhoids Treatments

Talking about “do external hemorrhoids go away completely”, you need to also consider several ways to treat hemorrhoids. And all those explanation is available in about getting rids of hemorrhoids. The home remedies include taking sitz bath, using witch hazel, staying hydrated by drinking more water, using stool softeners, sitting on air donut or rubber, and using ice pad. For the medical treatment, you can use OTC ointments, rubber band ligation, sclerotherapy and coagulation. Finally, when the hemorrhoids still persist after some treatments, you can take either hemorrhoidectomy or hemorrhoid stapling for the surgical procedures.

3 Most Effective Ways to Cover Baldness

 3 Most Effective Ways to Cover Baldness

If you are suffering from Alopecia or you are undergoing chemotherapy that causes your hair to start falling out, please don’t be sad. It is definitely hard, but keep your chin up and don’t let hair loss makes you lose your confidence. There are several hair replacement systems you can choose to help you cope with hair loss. Every method has its own advantages and the effectiveness will depend on your hair follicles and scalp condition. To help you make your choice, here are some of the best methods you can do to replace your hair.

Hair Transplant

Hair transplant is a surgical method where the doctor will move some hair from an area with plenty of hair to the bald area that you want to cover. When the hair has been moved, it will grow longer naturally just like what normal hair should be. This is a permanent solution to cover baldness because the doctors will prescribe some medication and topical treatment to prevent another hair loss in the future. Since this method requires moving your hair from one area to the other, it can only be performed on people that still have lots of hair in some areas.

Fashion Wigs

Fashion wig is the simplest solution to cover baldness. Wig is also pretty cheap and it comes with a lot of style and colors. You can choose whether you want to use natural or synthetic hair. Wig with natural hair is more expensive and it needs more treatment. But in the same time, it also looks more natural than the synthetic one. In the past, wig looked so ridiculous and sometimes it even resembled bird nest on our head. But now, wig is so light and beautiful. Even people who don’t experience baldness use it to transform their looks in a blink of an eye. As long as you use it right, no one’s going to realize that the hair is not real.

Cranial Prosthesis

Cranial prosthesis is actually similar with wigs. The only difference is it is mostly used by people with medical problems. The inside of the prosthesis is made of special material like silk, polyurethane or microline that gives more comfort to the skin. A person whose baldness is caused by medical condition usually has more sensitive and gentle skin. That’s why the prosthesis has to be custom made so that it can fit their head perfectly and will not cause any skin problems or discomfort.